We present a comprehensive and deep review of the HFM in challenges, opportunities, and future directions. The released paper: https://arxiv.org/abs/2404.03264
258
74 commits
updated Dec 13, 2024
[NEWS.20241115] Our survey paper has been accepted by IEEE Reviews in Biomedical Engineering (IF: 17.2).
[NEWS.20240405] The related survey paper has been released.
[NOTE] If you have any questions, please don't hesitate to contact us.
Foundation model, which is pre-trained on broad data and is able to adapt to a wide range of tasks, is advancing healthcare. It promotes the development of healthcare artificial intelligence (AI) models, breaking the contradiction between limited AI models and diverse healthcare practices. Much more widespread healthcare scenarios will benefit from the development of a healthcare foundation model (HFM), improving their advanced intelligent healthcare services.
This repository is a collection of AWESOME things about Foundation models in healthcare, including language foundation models (LFMs), vision foundation models (VFMs), bioinformatics foundation models (BFMs), and multimodal foundation models (MFMs). Feel free to star and fork.

This repository provides the advancement of current healthcare foundation models based on the following paper:
Foundation Model for Advancing Healthcare: Challenges, Opportunities and Future Directions 中译版
Yuting He, Fuxiang Huang, Xinrui Jiang, Yuxiang Nie, Minghao Wang, Jiguang Wang, Hao Chen
SMART Lab, Hong Kong University of Science and Technology
IEEE Reviews in Biomedical Engineering
If you find our survey beneficial to your work, we would greatly appreciate it if you cite it in your paper:
@ARTICLE{10750441,
author={He, Yuting and Huang, Fuxiang and Jiang, Xinrui and Nie, Yuxiang and Wang, Minghao and Wang, Jiguang and Chen, Hao},
journal={IEEE Reviews in Biomedical Engineering},
title={Foundation Model for Advancing Healthcare: Challenges, Opportunities and Future Directions},
year={2024},
volume={},
number={},
pages={1-20},
doi={10.1109/RBME.2024.3496744}}
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2020
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2024
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2021
2024
2023
2022
2021
| Dataset Name | Text Types | Scale | Task | Link |
|---|---|---|---|---|
| PubMed | Literature | 18B tokens | Language modeling | * |
| MedC-I | Literature | 79.2B tokens | Dialogue | * |
| Guidelines | Literature | 47K instances | Language modeling | * |
| PMC-Patients | Literature | 167K instances | Information retrieval | * |
| MIMIC-III | Health records | 122K instances | Language modeling | * |
| MIMIC-IV | Health record | 299K instances | Language modeling | * |
| eICU-CRDv2.0 | Health record | 200K instances | Language modeling | * |
| EHRs | Health record | 82B tokens | Named entity recognition, Relation extraction, Semantic textual similarity, Natural language inference, Dialogue | - |
| MD-HER | Health record | 96K instances | Dialogue, Question answering | - |
| IMCS-21 | Dialogue | 4K instances | Dialogue | * |
| Huatuo-26M | Dialogue | 26M instances | Question answering | * |
| MedInstruct-52k | Dialogue | 52K instances | Dialogue | * |
| MASH-QA | Dialogue | 35K instances | Dialogue | * |
| MedQuAD | Dialogue | 47K instances | Dialogue | * |
| MedDG | Dialogue | 17K instances | Dialogue | * |
| CMExam | Dialogue | 68K instances | Dialogue | * |
| cMedQA2 | Dialogue | 108K instances | Dialogue | * |
| CMtMedQA | Dialogue | 70K instances | Dialogue | * |
| CliCR | Dialogue | 100K instances | Dialogue | * |
| webMedQA | Dialogue | 63K instances | Dialogue | * |
| ChiMed | Dialogue | 1.59B tokens | Dialogue | * |
| MedDialog | Dialogue | 20K instances | Dialogue | * |
| CMD | Dialogue | 882K instances | Dialogue | * |
| BianqueCorpus | Dialogue | 2.4M instances | Dialogue | * |
| MedQA | Dialogue | 4K instances | Dialogue | * |
| HealthcareMagic | Dialogue | 100K instances | Dialogue | * |
| iCliniq | Dialogue | 10K instances | Dialogue | * |
| CMeKG-8K | Dialogue | 8K instances | Dialogue | * |
| Hybrid SFT | Dialogue | 226K instances | Dialogue | * |
| VariousMedQA | Dialogue | 54K instances | Dialogue | * |
| Medical Meadow | Dialogue | 160K instances | Dialogue | * |
| MultiMedQA | Dialogue | 193K instances | Dialogue | - |
| BiMed1.3M | Dialogue | 250K instances | Dialogue | * |
| OncoGPT | Dialogue | 180K instances | Dialogue | * |
| Dataset Name | Modality | Scale | Task | Link |
|---|---|---|---|---|
| LIMUC | Endoscopy | 1043 videos (11276 frames) | Detection | * |
| SUN | Endoscopy | 1018 videos (158,690 frames) | Detection | * |
| Kvasir-Capsule | Endoscopy | 117 videos (4,741,504 frames) | Detection | * |
| EndoSLAM | Endoscopy | 1020 videos (158,690 frames) | Detection, Registration | * |
| LDPolypVideo | Endoscopy | 263 videos (895,284 frames) | Detection | * |
| HyperKvasir | Endoscopy | 374 videos (1,059,519 frames) | Detection | * |
| CholecT45 | Endoscopy | 45 videos (90489 frames) | Segmentation, Detection | * |
| DeepLesion | CT slices (2D) | 32,735 images | Segmentation, Registration | * |
| LIDC-IDRI | 3D CT | 1,018 volumes | Segmentation | * |
| TotalSegmentator | 3D CT | 1,204 volumes | Segmentation | * |
| TotalSegmentatorv2 | 3D CT | 1,228 volumes | Segmentation | * |
| AutoPET | 3D CT, 3D PET | 1,214 PET-CT pairs | Segmentation | * |
| ULS | 3D CT | 38,842 volumes | Segmentation | * |
| FLARE 2022 | 3D CT | 2,300 volumes | Segmentation | * |
| FLARE 2023 | 3D CT | 4,500 volumes | Segmentation | * |
| AbdomenCT-1K | 3D CT | 1,112 volumes | Segmentation | * |
| CTSpine1K | 3D CT | 1,005 volumes | Segmentation | * |
| CTPelvic1K | 3D CT | 1,184 volumes | Segmentation | * |
| MSD | 3D CT, 3D MRI | 1,411 CT, 1,222 MRI | Segmentation | * |
| BraTS21 | 3D MRI | 2,040 volumes | Segmentation | * |
| BraTS2023-MEN | 3D MRI | 1,650 volumes | Segmentation | * |
| ADNI | 3D MRI | - | Clinical study | * |
| PPMI | 3D MRI | - | Clinical study | * |
| ATLAS v2.0 | 3D MRI | 1,271 volumes | Segmentation | * |
| PI-CAI | 3D MRI | 1,500 volumes | Segmentation | * |
| MRNet | 3D MRI | 1,370 volumes | Segmentation | * |
| Retinal OCT-C8 | 2D OCT | 24,000 volumes | Classification | * |
| Ultrasound Nerve Segmentation | US | 11,143 images | Segmentation | * |
| Fetal Planes | US | 12,400 images | Classification | * |
| EchoNet-LVH | US | 12,000 videos | Detection, Clinical study | * |
| EchoNet-Dynamic | US | 10,030 videos | Function assessment | * |
| AIROGS | CFP | 113,893 images | Classification | * |
| ISIC 2020 | Dermoscopy | 33,126 images | Classification | * |
| LC25000 | Pathology | 25,000 images | Classification | * |
| DeepLIIF | Pathology | 1,667 WSIs | Classification | * |
| PAIP | Pathology | 2,457 WSIs | Segmentation | * |
| TissueNet | Pathology | 1,016 WSIs | Classification | * |
| NLST | 3D CT, Pathology | 26,254 CT, 451 WSIs | Clinical study | * |
| CRC | Pathology | 100k images | Classification | * |
| MURA | X-ray | 40,895 images | Detection | * |
| ChestX-ray14 | X-ray | 112,120 images | Detection | * |
| SNOW | Synthetic pathology | 20K image tiles | Segmentation | * |
| Dataset Name | Modality | Scale | Task | Link |
|---|---|---|---|---|
| CellxGene Corpus | scRNA-seq | over 72M scRNA-seq data | Single cell omics study | * |
| NCBI GenBank | DNA | 3.7B sequences | Genomics study | * |
| SCP | scRNA-seq | over 40M scRNA-seq data | Single cell omics study | * |
| Gencode | DNA | Genomics study | * | |
| 10x Genomics | scRNA-seq, DNA | Single cell omics and genomics study | * | |
| ABC Atlas | scRNA-seq | over 15M scRNA-seq data | Single cell omics study | * |
| Human Cell Atlas | scRNA-seq | over 50M scRNA-seq data | Single cell omics study | * |
| UCSC Genome Browser | DNA | Genomics study | * | |
| CPTAC | DNA, RNA, protein | - | Genomics and proteomics study | * |
| Ensembl Project | Protein | Proteomics study | * | |
| RNAcentral database | RNA | 36M sequences | Transcriptomics study | * |
| AlphaFold DB | Protein | 214M structures | Proteomics study | * |
| PDBe | Protein | Proteomics study | * | |
| UniProt | Protein | over 250M sequences | Proteomics study | * |
| LINCS L1000 | Small molecules | 1,000 genes with 41k small molecules | Disease research, drug response | * |
| GDSC | Small molecules | 1,000 cancer cells with 400 compounds | Disease research, drug response | * |
| CCLE | Bioinformatics study | * |
| Dataset Name | Modalities | Scale | Task | Link |
|---|---|---|---|---|
| MIMIC-CXR | X-ray, Medical report | 377K images, 227K texts | Vision-Language Learning | * |
| PadChest | X-ray, Medical report | 160K images, 109K texts | Vision-Language Learning | * |
| CheXpert | X-ray, Medical report | 224K images, 224K texts | Vision-Language Learning | * |
| ImageCLEF2018 | Multimodal, Captions | 232K images, 232K texts | Image captioning | * |
| OpenPath | Pathology, Tweets | 208K images, 208K texts | Vision-Language learning | * |
| PathVQA | Pathology, QA | 4K images, 32K QA pairs | VQA | * |
| Quilt-1M | Pathology Images, Mixed-source text | 1M images, 1M texts | Vision-Language learning | * |
| PatchGastricADC22 | Pathology, Captions | 991 WSIs, 991 texts | Image captioning | * |
| PTB-XL | ECG, Medical report | 21K records, 21K texts | Vision-Language learning | * |
| ROCO | Multimodal, Captions | 87K images, 87K texts | Vision-Language learning | * |
| MedICaT | Multimodal, Captions | 217K images, 217K texts | Vision-Language learning | * |
| PMC-OA | Multimodal, Captions | 1.6M images, 1.6M texts | Vision-Language learning | * |
| ChiMed-VL | Multimodal, Medical report | 580K images, 580K texts | Vision-Language learning | * |
| PMC-VQA | Multimodal, QA | 149K images, 227K QA pairs | VQA | * |
| SwissProtCLAP | Protein Sequence, Text | 441K protein sequence, 441K texts | Protein-Language learning | * |
| Duke Breast Cancer MRI | Genomic, MRI images, Clinical data | 922 patients | Multimodal learning | * |
| I-SPY2 | MRI images, Clinical data | 719 patients | Multimodal learning | * |
| Database | Discription | Link |
|---|---|---|
| CGGA | Chinese Glioma Genome Atlas (CGGA) database contains clinical and sequencing data of over 2,000 brain tumor samples from Chinese cohorts. | * |
| UK Biobank | UK Biobank is a large-scale biomedical database and research resource containing de-identified genetic, lifestyle and health information and biological samples from half a million UK participants. | * |
| TCGA | The Cancer Genome Atlas program (TCGA) molecularly characterizes over 20,000 primary cancer, matches normal samples spanning 33 cancer types, and generates over 2.5 petabytes of genomic, epigenomic, transcriptomic, and proteomic data. | * |
| TCIA | The Cancer Imaging Archive (TCIA) is a service which de-identifies and hosts a large publicly available archive of medical images of cancer. | * |
We present a comprehensive and deep review of the HFM in challenges, opportunities, and future directions. The released paper: https://arxiv.org/abs/2404.03264
258
74 commits
updated Dec 13, 2024
[NEWS.20241115] Our survey paper has been accepted by IEEE Reviews in Biomedical Engineering (IF: 17.2).
[NEWS.20240405] The related survey paper has been released.
[NOTE] If you have any questions, please don't hesitate to contact us.
Foundation model, which is pre-trained on broad data and is able to adapt to a wide range of tasks, is advancing healthcare. It promotes the development of healthcare artificial intelligence (AI) models, breaking the contradiction between limited AI models and diverse healthcare practices. Much more widespread healthcare scenarios will benefit from the development of a healthcare foundation model (HFM), improving their advanced intelligent healthcare services.
This repository is a collection of AWESOME things about Foundation models in healthcare, including language foundation models (LFMs), vision foundation models (VFMs), bioinformatics foundation models (BFMs), and multimodal foundation models (MFMs). Feel free to star and fork.

This repository provides the advancement of current healthcare foundation models based on the following paper:
Foundation Model for Advancing Healthcare: Challenges, Opportunities and Future Directions 中译版
Yuting He, Fuxiang Huang, Xinrui Jiang, Yuxiang Nie, Minghao Wang, Jiguang Wang, Hao Chen
SMART Lab, Hong Kong University of Science and Technology
IEEE Reviews in Biomedical Engineering
If you find our survey beneficial to your work, we would greatly appreciate it if you cite it in your paper:
@ARTICLE{10750441,
author={He, Yuting and Huang, Fuxiang and Jiang, Xinrui and Nie, Yuxiang and Wang, Minghao and Wang, Jiguang and Chen, Hao},
journal={IEEE Reviews in Biomedical Engineering},
title={Foundation Model for Advancing Healthcare: Challenges, Opportunities and Future Directions},
year={2024},
volume={},
number={},
pages={1-20},
doi={10.1109/RBME.2024.3496744}}
2024
2023
2024
2023
2022
2021
2020
2019
2024
2023
2022
2021
2020
2019
2024
2022
2021
2024
2023
2022
2021
| Dataset Name | Text Types | Scale | Task | Link |
|---|---|---|---|---|
| PubMed | Literature | 18B tokens | Language modeling | * |
| MedC-I | Literature | 79.2B tokens | Dialogue | * |
| Guidelines | Literature | 47K instances | Language modeling | * |
| PMC-Patients | Literature | 167K instances | Information retrieval | * |
| MIMIC-III | Health records | 122K instances | Language modeling | * |
| MIMIC-IV | Health record | 299K instances | Language modeling | * |
| eICU-CRDv2.0 | Health record | 200K instances | Language modeling | * |
| EHRs | Health record | 82B tokens | Named entity recognition, Relation extraction, Semantic textual similarity, Natural language inference, Dialogue | - |
| MD-HER | Health record | 96K instances | Dialogue, Question answering | - |
| IMCS-21 | Dialogue | 4K instances | Dialogue | * |
| Huatuo-26M | Dialogue | 26M instances | Question answering | * |
| MedInstruct-52k | Dialogue | 52K instances | Dialogue | * |
| MASH-QA | Dialogue | 35K instances | Dialogue | * |
| MedQuAD | Dialogue | 47K instances | Dialogue | * |
| MedDG | Dialogue | 17K instances | Dialogue | * |
| CMExam | Dialogue | 68K instances | Dialogue | * |
| cMedQA2 | Dialogue | 108K instances | Dialogue | * |
| CMtMedQA | Dialogue | 70K instances | Dialogue | * |
| CliCR | Dialogue | 100K instances | Dialogue | * |
| webMedQA | Dialogue | 63K instances | Dialogue | * |
| ChiMed | Dialogue | 1.59B tokens | Dialogue | * |
| MedDialog | Dialogue | 20K instances | Dialogue | * |
| CMD | Dialogue | 882K instances | Dialogue | * |
| BianqueCorpus | Dialogue | 2.4M instances | Dialogue | * |
| MedQA | Dialogue | 4K instances | Dialogue | * |
| HealthcareMagic | Dialogue | 100K instances | Dialogue | * |
| iCliniq | Dialogue | 10K instances | Dialogue | * |
| CMeKG-8K | Dialogue | 8K instances | Dialogue | * |
| Hybrid SFT | Dialogue | 226K instances | Dialogue | * |
| VariousMedQA | Dialogue | 54K instances | Dialogue | * |
| Medical Meadow | Dialogue | 160K instances | Dialogue | * |
| MultiMedQA | Dialogue | 193K instances | Dialogue | - |
| BiMed1.3M | Dialogue | 250K instances | Dialogue | * |
| OncoGPT | Dialogue | 180K instances | Dialogue | * |
| Dataset Name | Modality | Scale | Task | Link |
|---|---|---|---|---|
| LIMUC | Endoscopy | 1043 videos (11276 frames) | Detection | * |
| SUN | Endoscopy | 1018 videos (158,690 frames) | Detection | * |
| Kvasir-Capsule | Endoscopy | 117 videos (4,741,504 frames) | Detection | * |
| EndoSLAM | Endoscopy | 1020 videos (158,690 frames) | Detection, Registration | * |
| LDPolypVideo | Endoscopy | 263 videos (895,284 frames) | Detection | * |
| HyperKvasir | Endoscopy | 374 videos (1,059,519 frames) | Detection | * |
| CholecT45 | Endoscopy | 45 videos (90489 frames) | Segmentation, Detection | * |
| DeepLesion | CT slices (2D) | 32,735 images | Segmentation, Registration | * |
| LIDC-IDRI | 3D CT | 1,018 volumes | Segmentation | * |
| TotalSegmentator | 3D CT | 1,204 volumes | Segmentation | * |
| TotalSegmentatorv2 | 3D CT | 1,228 volumes | Segmentation | * |
| AutoPET | 3D CT, 3D PET | 1,214 PET-CT pairs | Segmentation | * |
| ULS | 3D CT | 38,842 volumes | Segmentation | * |
| FLARE 2022 | 3D CT | 2,300 volumes | Segmentation | * |
| FLARE 2023 | 3D CT | 4,500 volumes | Segmentation | * |
| AbdomenCT-1K | 3D CT | 1,112 volumes | Segmentation | * |
| CTSpine1K | 3D CT | 1,005 volumes | Segmentation | * |
| CTPelvic1K | 3D CT | 1,184 volumes | Segmentation | * |
| MSD | 3D CT, 3D MRI | 1,411 CT, 1,222 MRI | Segmentation | * |
| BraTS21 | 3D MRI | 2,040 volumes | Segmentation | * |
| BraTS2023-MEN | 3D MRI | 1,650 volumes | Segmentation | * |
| ADNI | 3D MRI | - | Clinical study | * |
| PPMI | 3D MRI | - | Clinical study | * |
| ATLAS v2.0 | 3D MRI | 1,271 volumes | Segmentation | * |
| PI-CAI | 3D MRI | 1,500 volumes | Segmentation | * |
| MRNet | 3D MRI | 1,370 volumes | Segmentation | * |
| Retinal OCT-C8 | 2D OCT | 24,000 volumes | Classification | * |
| Ultrasound Nerve Segmentation | US | 11,143 images | Segmentation | * |
| Fetal Planes | US | 12,400 images | Classification | * |
| EchoNet-LVH | US | 12,000 videos | Detection, Clinical study | * |
| EchoNet-Dynamic | US | 10,030 videos | Function assessment | * |
| AIROGS | CFP | 113,893 images | Classification | * |
| ISIC 2020 | Dermoscopy | 33,126 images | Classification | * |
| LC25000 | Pathology | 25,000 images | Classification | * |
| DeepLIIF | Pathology | 1,667 WSIs | Classification | * |
| PAIP | Pathology | 2,457 WSIs | Segmentation | * |
| TissueNet | Pathology | 1,016 WSIs | Classification | * |
| NLST | 3D CT, Pathology | 26,254 CT, 451 WSIs | Clinical study | * |
| CRC | Pathology | 100k images | Classification | * |
| MURA | X-ray | 40,895 images | Detection | * |
| ChestX-ray14 | X-ray | 112,120 images | Detection | * |
| SNOW | Synthetic pathology | 20K image tiles | Segmentation | * |
| Dataset Name | Modality | Scale | Task | Link |
|---|---|---|---|---|
| CellxGene Corpus | scRNA-seq | over 72M scRNA-seq data | Single cell omics study | * |
| NCBI GenBank | DNA | 3.7B sequences | Genomics study | * |
| SCP | scRNA-seq | over 40M scRNA-seq data | Single cell omics study | * |
| Gencode | DNA | Genomics study | * | |
| 10x Genomics | scRNA-seq, DNA | Single cell omics and genomics study | * | |
| ABC Atlas | scRNA-seq | over 15M scRNA-seq data | Single cell omics study | * |
| Human Cell Atlas | scRNA-seq | over 50M scRNA-seq data | Single cell omics study | * |
| UCSC Genome Browser | DNA | Genomics study | * | |
| CPTAC | DNA, RNA, protein | - | Genomics and proteomics study | * |
| Ensembl Project | Protein | Proteomics study | * | |
| RNAcentral database | RNA | 36M sequences | Transcriptomics study | * |
| AlphaFold DB | Protein | 214M structures | Proteomics study | * |
| PDBe | Protein | Proteomics study | * | |
| UniProt | Protein | over 250M sequences | Proteomics study | * |
| LINCS L1000 | Small molecules | 1,000 genes with 41k small molecules | Disease research, drug response | * |
| GDSC | Small molecules | 1,000 cancer cells with 400 compounds | Disease research, drug response | * |
| CCLE | Bioinformatics study | * |
| Dataset Name | Modalities | Scale | Task | Link |
|---|---|---|---|---|
| MIMIC-CXR | X-ray, Medical report | 377K images, 227K texts | Vision-Language Learning | * |
| PadChest | X-ray, Medical report | 160K images, 109K texts | Vision-Language Learning | * |
| CheXpert | X-ray, Medical report | 224K images, 224K texts | Vision-Language Learning | * |
| ImageCLEF2018 | Multimodal, Captions | 232K images, 232K texts | Image captioning | * |
| OpenPath | Pathology, Tweets | 208K images, 208K texts | Vision-Language learning | * |
| PathVQA | Pathology, QA | 4K images, 32K QA pairs | VQA | * |
| Quilt-1M | Pathology Images, Mixed-source text | 1M images, 1M texts | Vision-Language learning | * |
| PatchGastricADC22 | Pathology, Captions | 991 WSIs, 991 texts | Image captioning | * |
| PTB-XL | ECG, Medical report | 21K records, 21K texts | Vision-Language learning | * |
| ROCO | Multimodal, Captions | 87K images, 87K texts | Vision-Language learning | * |
| MedICaT | Multimodal, Captions | 217K images, 217K texts | Vision-Language learning | * |
| PMC-OA | Multimodal, Captions | 1.6M images, 1.6M texts | Vision-Language learning | * |
| ChiMed-VL | Multimodal, Medical report | 580K images, 580K texts | Vision-Language learning | * |
| PMC-VQA | Multimodal, QA | 149K images, 227K QA pairs | VQA | * |
| SwissProtCLAP | Protein Sequence, Text | 441K protein sequence, 441K texts | Protein-Language learning | * |
| Duke Breast Cancer MRI | Genomic, MRI images, Clinical data | 922 patients | Multimodal learning | * |
| I-SPY2 | MRI images, Clinical data | 719 patients | Multimodal learning | * |
| Database | Discription | Link |
|---|---|---|
| CGGA | Chinese Glioma Genome Atlas (CGGA) database contains clinical and sequencing data of over 2,000 brain tumor samples from Chinese cohorts. | * |
| UK Biobank | UK Biobank is a large-scale biomedical database and research resource containing de-identified genetic, lifestyle and health information and biological samples from half a million UK participants. | * |
| TCGA | The Cancer Genome Atlas program (TCGA) molecularly characterizes over 20,000 primary cancer, matches normal samples spanning 33 cancer types, and generates over 2.5 petabytes of genomic, epigenomic, transcriptomic, and proteomic data. | * |
| TCIA | The Cancer Imaging Archive (TCIA) is a service which de-identifies and hosts a large publicly available archive of medical images of cancer. | * |