soup-connectome

Inspired by Soup
Portable runtime for executing sparse biological connectomes across CPU, CUDA, WebGPU, and WASM.

v0.1.0 · MaleCNS · Browser runtime

soup-connectome turns a sparse connectome into a portable .scx artifact and executes it with deterministic fixed-point LIF semantics. The first dataset target is MaleCNS, the male fruit-fly connectome released by Janelia.

Built with ideas from Soup. This is an independent infrastructure experiment that carries Soup's streamed sparse-graph approach into a real biological connectome runtime. Soup is the architectural inspiration, not a bundled runtime dependency or a claim of official endorsement.

This is infrastructure, not a game demo: the project focuses on graph storage, streaming, backend parity, and explicit device planning. It does not claim biological validation.

Status at a glance

Full-scale benchmark

measured on the local host · 211,577 neurons · 24,678,466 edges · three streamed CSR blocks

The reproducible standard run uses threshold=20000, reset=0, decay_shifts=[2], refractory_steps=2, --timesteps 4, --seed-neuron 0, and --seed-potential 30000.

python scripts/benchmark_malecns.py --device cpu --residency streamed --timesteps 4
python scripts/benchmark_malecns.py --device webgpu --residency streamed --timesteps 4

These numbers are reproducibility evidence for the runtime, not a throughput claim or biological calibration. Additional one-timestep smoke and synthetic propagation results are recorded below.

Additional validation runs

Run	Result
Full-scale, one timestep, zero initial spikes, CPU	2.245442 s, 0 spikes — measured
Full-scale, one timestep, zero initial spikes, Python WebGPU	2.695649 s, 0 spikes — measured
Full-scale, two-timestep active synthetic stress, CPU	130.364592 s, spike counts [1, 319] — measured
Same active synthetic stress, Python WebGPU	128.487143 s, spike counts [1, 319] — measured

The active stress configuration uses threshold=1, reset=0, decay_shifts=[31], and refractory_steps=0; it is a propagation test, not a biological calibration or representative throughput benchmark.

Why this runtime

Large sparse graphs create a different deployment problem from a conventional dense neural model. The runtime keeps neuron state and the delay line resident while streaming sparse source blocks, so graph residency is an explicit axis:

MaleCNS Feather files
        │
        ▼
local adapter + sign mapping
        │
        ▼
portable .scx artifact
        │
        ├── CPU resident / streamed
        ├── CUDA resident / streamed
        ├── Python WebGPU resident / streamed
        └── browser WebGPU streamed / WASM CPU fallback

Streaming is a memory-shape and portability feature. It is not automatically a throughput guarantee: the current streamed accelerator paths validate and transfer one active source block at a time and do not use a prefetch cache.

Quick start

Install the core package and development/data extras:

python -m pip install -e ".[dev,data]"

Optional backends:

python -m pip install -e ".[dev,data,cuda]"
python -m pip install -e ".[dev,data,webgpu]"

Run the deterministic fixture:

soup-connectome run --dataset example --device cpu
soup-connectome run --dataset example --device cpu --residency streamed
soup-connectome run --dataset example --device webgpu --residency streamed
soup-connectome plan --dataset example --device cpu

Explicit cuda and webgpu never silently fall back to CPU. auto resolves to CPU by design.

MaleCNS data workflow

The adapter is local-only and never downloads data automatically. It requires:

• connection weights;
• body annotations;
• body neurotransmitters.

For the verified MaleCNS v1.0 download, the measured columns are:

Inspect local schemas first:

soup-connectome inspect --file path/to/body-annotations.feather
soup-connectome inspect --file path/to/body-neurotransmitters.feather

The first artifact uses the curated annotation node filter and this explicit sign mapping:

soup-connectome convert \
  --weights data/male-cns/connectome-weights-male-cns-v1.0-minconf-0.5.feather \
  --annotations data/male-cns/body-annotations-male-cns-v1.0-minconf-0.5.feather \
  --neurotransmitters data/male-cns/body-neurotransmitters-male-cns-v1.0.feather \
  --output artifacts/male-cns-v1.0-annotated.scx \
  --annotation-id bodyId \
  --annotation-type type \
  --annotation-side somaSide \
  --neurotransmitter-id body \
  --neurotransmitter-name consensus_nt \
  --sign-mapping '{"acetylcholine": 1, "gaba": -1, "glutamate": 1}' \
  --exclude-neurotransmitter unclear \
  --exclude-neurotransmitter dopamine \
  --exclude-neurotransmitter histamine \
  --exclude-neurotransmitter octopamine \
  --exclude-neurotransmitter serotonin \
  --exclude-neurotransmitter unknown \
  --scope full \
  --node-filter annotations

The local download measured 151,856,684 weight rows, 211,577 annotation rows, 1,835,518 neurotransmitter rows, and 1,109,008,094 bytes across the three Feather files. These are measurements for this exact download, not universal hardware requirements. Raw data, generated artifacts, WASM build outputs, and browser test results are intentionally ignored by Git.

Runtime contract

The backend-independent simulation contract uses:

• signed int32 membrane potentials;
• signed int16 synaptic impulses;
• positive integer timestep delays;
• checked arithmetic with rejected overflow;
• arithmetic-shift leak: V := V - (V >> k).

These are representation choices, not measured biological constants.

Development and tests

python -m pytest -q
python -m ruff check .
python -m ruff format --check .

cd web
npm test
npm run test:e2e

cd wasm
cargo fmt --check
cargo test
cargo check --target wasm32-unknown-unknown

The repository uses three evidence labels:

• measured — produced by an actual local run or benchmark;
• estimated — a design calculation or planning assumption;
• not tested — no local evidence yet.

Limitations

• No biological calibration or scientific fidelity claim is made.
• Morphology and EM-volume simulation are out of scope for the current phase.
• Automatic MaleCNS downloads and a networked data pipeline are not included.
• Full-scale active stress is measured for two timesteps with a synthetic configuration; longer runs on the Python reference path are not tested.
• Browser compatibility across GPU vendors and operating systems is not tested.

Repository map

src/soup_connectome/   runtime, graph format, adapters, backends, CLI
scripts/                reproducible full-scale benchmark entry point
tests/                 Python contract and parity tests
web/src/               browser WebGPU and WASM streaming host
web/wasm/              wasm-bindgen CPU runtime
web/test/              browser parity fixture
docs/                  project documentation

References

• MaleCNS
• MaleCNS download
• Soup
• Google Research connectomics announcement